Microglial cathepsin B is necessary for neuronal efferocytosis in zebrafish and mice during brain development.
Silva, N.J., Anderson, S.R., Mula, S.A, Escoubas, C.C, Nakajo, H, and Molofsky, A.V.. Nature Communications
[PubMed]
Extracellular matrix proteolysis maintains synapse plasticity during brain development.
Nakajo H, Cao R, Mula S.A., Mcketney J, Silva N.J., Li K.H., Chalkley R.J., Randolph L, Shah M, Rose I.V.L., Kampmann M, Swaney D.L., Kirst C, Molofsky A.V.. Nature Neuroscience
[PubMed]
A type I interferon response defines a conserved microglial state required for effective neuronal phagocytosis.
Escoubas C.C., Dorman L.C., Nguyen P.T., Lagares-Linares C, Nakajo H, Anderson S.R., Barron J.J., Wade S.D., Cuevas B, Vainchtein ID, Silva NJ, Guajardo R, Xiao Y, Lidsky P.V., Wang E.Y., Rivera B.M., Taloma S.E., Kim D.K., Kaminskaya E, Nakao-Inoue H, Schwer B, Arnold T.D., Molofsky A.B., Condello C, Andino R, Nowakowski T.J., Molofsky A.V.. Cell 187 (8):1936-1954
[PubMed]
Common and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina.
Lyu P, Iribarne M, Serjanov D, Zhai Y, Hoang T, Campbell L, Boyd P, Palazzo I, Nagashima M, Silva N.J, Hitchcock P, Qian J, Hyde D, Blackshaw S. Nature Communications 14 (1): 8477
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In situ and transcriptomic identification of microglia in synapse rich regions of the developing zebrafish brain.
Silva N.J., Dorman L.C., Vainchtein I.D., Horneck N.C., Molofsky A.V.. Nature Communications 12 (1):5916
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Inflammation and matrix metalloproteinase 9 (Mmp-9) regulate photoreceptor regeneration in adult zebrafish.
Silva N.J., Nagashima M, Li J, M, Ashrafzadeh, M, Kakuk-Atkins L, Hyde D, Hitchcock P.F.. Glia 68(7):1445-1465
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Divergent mechanisms for regulation of growth and development after imaginal disc damage in the tobacco hornworm.
Rosero M.A, Abdon B, Silva N.J, Cisneros B, Makunts, T, Zavaleta J.A, Miry O, Ramos L.S, Bashar J, Moffatt A.C, Fuse M. Journal of Experimental Biology 222(pt 20):jeb200352
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Pregnancy diet based on ancestral patterns increases growth in subcortical fetal brain regions.
Lora L Iannotti, Gabriela Vintimilla Andrade, Shirley Tipanquiza Piedra, Rachel B Zimmerman, Elizabeth Hahn, Pamela Camana, Dessire Baldeon, Paul Silva, Karen Balladares, Carlos Andres Gallegos-Riofrio, Melissa Chapnick, Gifty Aboagye-Mensah, Timothy Zielonko, Marcus Raichle, Manu S Goyal, William F Waters, Iván Palacios León, Jennifer Nicholas.
Proc Natl Acad Sci U S A. 2026 Sep 8;123(36):e2602218123. doi: 10.1073/pnas.2602218123. Epub 2026 Aug 31.
Critical care unit bed availability and postoperative outcomes: a multinational cohort study.
Ruaraidh A S Campbell, Tharusan Thevathasan, Danny J N Wong, Andrew M Wilson, Helen A Lindsay, Douglas Campbell, Scott Popham, Lisa M Barneto, Paul S Myles, S Ramani Moonesinghe, SNAP‐2: EPICCS collaborators, Steve K Harris.
Anaesthesia. 2024 Nov;79(11):1165-1179. doi: 10.1111/anae.16383. Epub 2024 Sep 26.
A prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
NIHR Global Health Research Unit on Global Surgery, STARSurg Collaborative.
Lancet Digit Health. 2024 Jul;6(7):e507-e519. doi: 10.1016/S2589-7500(24)00065-7.
Thalamic atrophy and dysconnectivity are associated with cognitive impairment in a multi-center, clinical routine, real-word study of people with relapsing-remitting multiple sclerosis.
Robert Zivadinov, Niels Bergsland, Dejan Jakimovski, Bianca Weinstock-Guttman, Lorena Lorefice, Menno M Schoonheim, Sarah A Morrow, Mary Ann Picone, Gabriel Pardo, Myassar Zarif, Mark Gudesblatt, Jacqueline A Nicholas, Andrew Smith, Samuel Hunter, Stephen Newman, Mahmoud A AbdelRazek, Ina Hoti, Jon Riolo, Diego Silva, Tom A Fuchs, Michael G Dwyer, Ralph Hb Benedict.
Neuroimage Clin. 2024;42:103609. doi: 10.1016/j.nicl.2024.103609. Epub 2024 Apr 27.
Thalamic atrophy measured by artificial intelligence in a multicentre clinical routine real-word study is associated with disability progression.
Robert Zivadinov, Niels Bergsland, Dejan Jakimovski, Bianca Weinstock-Guttman, Ralph H B Benedict, Jon Riolo, Diego Silva, Michael G Dwyer, DeepGRAI Registry Study group.
J Neurol Neurosurg Psychiatry. 2022 Jul 28:jnnp-2022-329333. doi: 10.1136/jnnp-2022-329333. Online ahead of print.
Evaluation of prognostic risk models for postoperative pulmonary complications in adult patients undergoing major abdominal surgery: a systematic review and international external validation cohort study.
STARSurg Collaborative and TASMAN Collaborative.
Lancet Digit Health. 2022 Jul;4(7):e520-e531. doi: 10.1016/S2589-7500(22)00069-3.
Death following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic.
STARSurg Collaborative and COVIDSurg Collaborative.
Br J Surg. 2021 Dec 1;108(12):1448-1464. doi: 10.1093/bjs/znab336.
Preliminary model assessing the cost-effectiveness of preoperative chlorhexidine mouthwash at reducing postoperative pneumonia among abdominal surgery patients in South Africa.
Mwayi Kachapila, Adesoji O Ademuyiwa, Bruce M Biccard, Dhruva N Ghosh, James Glasbey, Mark Monahan, Rachel Moore, Dion G Morton, Raymond Oppong, Rupert Pearse, Tracy E Roberts, NIHR Global Health Research Unit on Global Surgery, ASOS Investigators, STARSurg Collaborative.
PLoS One. 2021 Aug 12;16(8):e0254698. doi: 10.1371/journal.pone.0254698. eCollection 2021.
Four consecutive yearly point-prevalence studies in Wales indicate lack of improvement in sepsis care on the wards.
Maja Kopczynska, Harry Unwin, Richard J Pugh, Ben Sharif, Thomas Chandy, Daniel J Davies, Matthew E Shield, David E Purchase, Samuel C Tilley, Arwel Poacher, Lewis Oliva, Sam Willis, Isabelle E Ray, John Ng C Hui, Bethany C Payne, Eilis F Wardle, Fiona Andrew, Hei Man Priscilla Chan, Jack Barrington, Jay Hale, Joanna Hawkins, Jess K Nicholas, Lara E Wirt, Lowri H Thomas, Megan Walker, Myat P Pan, Tallulah Ray, Umair H Asim, Victoria Maidman, Zeid Atiyah, Zain M Nasser, Zhao Xuan Tan, Laura J P Tan, Tamas Szakmany, Welsh Digital Data Collection Platform collaborators.
Sci Rep. 2021 Aug 10;11(1):16222. doi: 10.1038/s41598-021-95648-6.
Age-Dependent Heterogeneity in the Efficacy of Prophylaxis With Enoxaparin Against Catheter-Associated Thrombosis in Critically Ill Children: A Post Hoc Analysis of a Bayesian Phase 2b Randomized Clinical Trial.
E Vincent S Faustino, Leslie J Raffini, Sheila J Hanson, Jill M Cholette, Matthew G Pinto, Simon Li, Sarah B Kandil, Marianne E Nellis, Veronika Shabanova, Cicero T Silva, Joana A Tala, Tara McPartland, Philip C Spinella, for the
CRETE Trial
Investigators and the Pediatric Critical Care Blood Research Network (BloodNet) of the Pediatric Acute Lung Injury and Sepsis Investigators Network (PALISI), CRETE Trial Investigators: Clinical Coordinating Center:, and, Data Coordinating Center:, and, Outcomes Adjudication Committee:, and, Data and Safety Monitoring Board:, and, Independent Safety Monitor:, and, Children’s Hospital Wisconsin:, and, Dell Children’s Medical Center:, and, Maria Fareri Children’s Hospital:, and, St. Louis Children’s Hospital:, and, University of Rochester Golisano Children’s Hospital:, and, Weill Cornell Medical Center:, and, and Yale-New Haven Children’s Hospital:, and, for the
CRETE Trial
Investigators and the Pediatric Critical Care Blood Research Network (BloodNet) of the Pediatric Acute Lung Injury and Sepsis Investigators Network (PALISI) and CRETE Trial Investigators: Clinical Coordinating Center: and and and Data Coordinating Center: and and and Outcomes Adjudication Committee: and and and Data and Safety Monitoring Board: and and and Independent Safety Monitor: and and and Children’s Hospital Wisconsin: and and and Dell Children’s Medical Center: and and and Maria Fareri Children’s Hospital: and and and St. Louis Children’s Hospital: and and and University of Rochester Golisano Children’s Hospital: and and and Weill Cornell Medical Center: and and and and Yale-New Haven Children’s Hospital: and and.
Crit Care Med. 2021 Apr 1;49(4):e369-e380. doi: 10.1097/CCM.0000000000004848.
Cancelled operations: a 7-day cohort study of planned adult inpatient surgery in 245 UK National Health Service hospitals.
D J N Wong, S K Harris, S R Moonesinghe, SNAP-2: EPICCS collaborators, Health Services Research Centre, National Institute of Academic Anaesthesia, Study Steering Group, Net Solving Limited, Trainee Research Networks, Abertawe Bro Morgannwg University Health Board, Aintree University Hospitals NHS Foundation Trust, Airedale NHS Foundation Trust, Aneurin Bevan Health Board, Ashford & St Peters NHS Foundation Trust, Barking, Havering and Redbridge University Hospitals NHS Trust, Barnsley Hospital NHS Foundation Trust, Barts Health NHS Trust, Basildon and Thurrock University Hospitals NHS Foundation Trust, Bedford Hospital NHS Trust, Belfast Health and Social Care Trust, Betsi Cadwaladr University Health Board, Birmingham Women's NHS Foundation Trust, Blackpool Teaching Hospitals NHS Foundation Trust, Bolton Hospital NHS Foundation Trust, Bradford Teaching Hospitals NHS Foundation Trust, Brighton and Sussex University Hospitals NHS Trust, Buckinghamshire Healthcare NHS Trust, Burton Hospitals NHS Foundation Trust, Calderdale and Huddersfield NHS Foundation Trust, Cambridge University Hospitals NHS Foundation Trust, Cardiff and Vale University Health Board, Central Manchester University Hospitals NHS Foundation Trust, Chelsea and Westminster Hospital NHS Foundation Trust, Chesterfield Royal Hospital NHS Foundation Trust, Christie Hospital NHS Foundation Trust, City Hospitals Sunderland NHS Foundation Trust, Colchester Hospital University NHS Foundation Trust, Countess of Chester NHS Foundation Trust, County Durham and Darlington NHS Foundation Trust, Croydon Health Services NHS Trust, Cwm Taf University Health Board, Dartford and Gravesham NHS Trust, Derby Hospitals NHS Foundation Trust, Doncaster and Bassetlaw Hospitals NHS Foundation Trust, Dorset County Hospital NHS Foundation Trust, Dudley Group NHS Foundation Trust, East and North Hertfordshire NHS Trust, East Kent Hospitals University NHS Foundation Trust, East Lancashire Hospitals NHS Trust, East Sussex Healthcare NHS Trust, Epsom and St Helier University Hospitals NHS Trust, Frimley Health NHS Foundation Trust, Gateshead Health NHS Foundation Trust, Gloucestershire Hospitals NHS Foundation Trust, Great Western Hospitals NHS Foundation Trust, Guy's and St Thomas' NHS Foundation Trust, Hampshire Hospitals NHS Foundation Trust, Harrogate and District NHS Foundation Trust, Heart Of England NHS Foundation Trust, Hillingdon Hospitals NHS Foundation Trust, Homerton University Hospital NHS Foundation Trust, Hull and East Yorkshire Hospitals NHS Trust, Hywel Dda Health Board, Imperial College Healthcare NHS Trust, Ipswich Hospital NHS Trust, Isle of Wight NHS Trust, James Paget University Hospitals NHS Foundation Trust, Kettering General Hospital NHS Foundation Trust, King's College Hospital NHS Foundation Trust, Kingston Hospital NHS Foundation Trust, Lancashire Teaching Hospitals NHS Foundation Trust, Leeds Teaching Hospitals NHS Trust, Lewisham and Greenwich NHS Trust, Liverpool Women's NHS Foundation Trust, Luton and Dunstable University Hospital NHS Foundation Trust, Medway NHS Foundation Trust, Mid Cheshire Hospitals NHS Foundation Trust, Mid Essex Hospital Services NHS Trust, Mid Yorkshire Hospitals NHS Trust, Milton Keynes University Hospital NHS Foundation Trust, Newcastle upon Tyne Hospitals NHS Foundation Trust, NHS Ayrshire & Arran, NHS Dumfries & Galloway, NHS Fife, NHS Greater Glasgow & Clyde, NHS Highland, NHS Lanarkshire, NHS Lothian, NHS Scotland Special Board, NHS Shetland, NHS Tayside, Norfolk and Norwich University Hospitals NHS Foundation Trust, Northampton General Hospital NHS Trust, North Bristol NHS Trust, North Cumbria University Hospitals NHS Trust, Northern Devon Healthcare NHS Trust, Northern Health and Social Care Trust, Northern Lincolnshire and Goole Hospitals NHS Foundation Trust, North Middlesex University Hospital NHS Trust, North Tees and Hartlepool NHS Trust, Northumbria Healthcare NHS Foundation Trust, North West Anglia NHS Foundation Trust, Nottingham University Hospitals NHS Trust, Oxford University Hospitals NHS Foundation Trust, Papworth Hospital NHS Foundation Trust, Pennine Acute NHS Trust, Plymouth Hospitals NHS Trust, Poole Hospital NHS Foundation Trust, Portsmouth Hospitals NHS Trust, Princess Alexandra Hospital NHS Trust, Queen Elizabeth Hospital NHS Foundation Trust, Queen Victoria Hospital NHS Foundation Trust, Robert Jones and Agnes Hunt Orthopaedic Hospital Foundation Trust, Rotherham NHS Foundation Trust, Royal Berkshire NHS Foundation Trust, Royal Bournemouth & Christchurch Hospitals NHS Foundation Trust, Royal Cornwall Hospitals NHS Trust, Royal Devon and Exeter NHS Foundation Trust, Royal Free London NHS Foundation Trust, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Royal Marsden NHS Foundation Trust, Royal National Orthopaedic Hospital NHS Trust, Royal Orthopaedic Hospital NHS Foundation Trust, Royal Surrey County Hospital NHS Foundation Trust, Royal United Hospitals Bath NHS Trust, Royal Wolverhampton Hospitals NHS Trust, Salford Royal NHS Foundation Trust, Salisbury NHS Foundation Trust, Sandwell and West Birmingham Hospitals NHS Trust, Sheffield Teaching Hospitals NHS Foundation Trust, Shrewsbury and Telford Hospital NHS Trust, South Eastern Health and Social Care Trust, Southport and Ormskirk Hospital NHS Trust, South Tees Hospitals NHS Foundation Trust, South Tyneside NHS Foundation Trust, South Warwickshire NHS Foundation Trust, St George's Healthcare NHS Trust, St Helens and Knowsley Teaching Hospitals NHS Trust, Stockport NHS Foundation Trust, Surrey and Sussex Healthcare NHS Trust, Tameside Hospital NHS Foundation Trust, Taunton and Somerset NHS Foundation Trust, Torbay and South Devon NHS Foundation Trust, United Lincolnshire Hospitals NHS Trust, University College London Hospitals NHS Foundation Trust, University Hospital of North Midlands NHS Trust, University Hospital of South Manchester NHS Foundation Trust, University Hospitals Birmingham NHS Foundation Trust, University Hospitals Bristol NHS Foundation Trust, University Hospitals Coventry and Warwickshire NHS Trust, University Hospitals of Leicester NHS Trust, University Hospitals of Morecambe Bay NHS Foundation Trust, University Hospital Southampton NHS Foundation Trust, Walsall Healthcare NHS Trust, Warrington & Halton Hospitals NHS Foundation Trust, Western Health and Social Care Trust, Western Sussex Hospitals NHS Foundation Trust, West Herts Hospitals NHS Trust, Weston Area Health NHS Trust, West Suffolk NHS Foundation Trust, Whittington Hospital NHS Trust, Wirral University Teaching Hospital NHS Foundation Trust, Worcestershire Acute Hospitals NHS Trust, Wrightington, Wigan and Leigh NHS Foundation Trust, Wye Valley NHS Trust, Yeovil District Hospital NHS Foundation Trust, York Teaching Hospital NHS Foundation Trust.
Br J Anaesth. 2018 Oct;121(4):730-738. doi: 10.1016/j.bja.2018.07.002. Epub 2018 Sep 7.
A cognitive chameleon: lessons from a novel MAPT mutation case.
Yuying Liang, Elizabeth Gordon, Jonathan Rohrer, Laura Downey, Rohan de Silva, Hans Rolf Jäger, Jennifer Nicholas, Marc Modat, M Jorge Cardoso, Colin Mahoney, Jason Warren, Martin Rossor, Nick Fox, Diana Caine.
Neurocase. 2014;20(6):684-94. doi: 10.1080/13554794.2013.826697. Epub 2013 Sep 2.


